The relationships between cyclic AMP, calcium and prostaglandins as second messengers
Identifieur interne : 003944 ( Main/Exploration ); précédent : 003943; suivant : 003945The relationships between cyclic AMP, calcium and prostaglandins as second messengers
Auteurs : D. F. Horrobin [Canada] ; M. S. Manku [Canada] ; R. A. Karmali [Canada] ; A. I. Ally [Canada] ; M. Karmazyn [Canada] ; R. O. Morgan [Canada]Source :
- Medical Hypotheses [ 0306-9877 ] ; 1977.
English descriptors
- Teeft :
- Academic press, Activator, Adenosine, Adenyl cyclase, Adenylate cyclase, Allosteric, Allosteric site, Antagonist, Binding sites, Biochemical aspects, Biol, Biol chem, Biological effects, Blood vessels, Calcium ions, Camp synthesis, Carbonic anhydrase, Cation, Cell preparations, Cellular activity, Cyclase, Cyclic, Cyclic nucleotide, Cyclic nucleotides, Dibutyryl compound, Enzyme activity, Essential growth factor, Hormone action, Horrobin, Indomethacin, Inhibitor, Inhibitory activity, Karmazyn, Kinase, Local anaesthetics, Mammary gland, Manku, Many experiments, Mesenteric artery preparation, Methyl xanthines, Natural compounds, Nucleic, Nucleic acid function, Nucleic acids, Nucleotide, Opiate receptors, Pharmacol, Phosphodiesterase, Phosphodiesterase inhibitors, Physiol pharmacol, Polypeptide hormones, Prolactin, Prostaglandin, Prostaglandin actions, Prostaglandin agonists, Prostaglandin antagonist, Prostaglandin antagonists, Prostaglandin biosynthesis, Prostaglandin outflow, Prostaglandin production, Prostaglandin synthesis, Protein activator, Protein kinase, Receptor, Regulator, Regulator molecules, Regulatory subunit, Same sites, Second messenger, Second messengers, Side effects, Similar mechanisms, Smooth muscle, Steroid, Steroid hormones, Subunit, Theophylline, Xanthine.
Abstract
Abstract: There is considerable dissatisfaction with present second messenger hypotheses involving cyclic nucleotides and calcium. The recent findings that methyl xanthines and adenosine are prostaglandin antagonists casts doubt on much of the evidence in favour of the cyclic AMP hypothesis. There is evidence that allosteric sites may modify the binding of calcium and cyclic nucleotides to key cellular regulators and that a range of substances including steroids, adenosine and prostaglandins may occupy those sites. This concept introduces much needed flexibility into the second messenger concept, allows many experiments to be reinterpreted and has major implications throughout the biomedical sciences.
Url:
DOI: 10.1016/0306-9877(77)90038-X
Affiliations:
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The recent findings that methyl xanthines and adenosine are prostaglandin antagonists casts doubt on much of the evidence in favour of the cyclic AMP hypothesis. There is evidence that allosteric sites may modify the binding of calcium and cyclic nucleotides to key cellular regulators and that a range of substances including steroids, adenosine and prostaglandins may occupy those sites. This concept introduces much needed flexibility into the second messenger concept, allows many experiments to be reinterpreted and has major implications throughout the biomedical sciences.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement></list><tree><country name="Canada"><region name="Québec"><name sortKey="Horrobin, D F" sort="Horrobin, D F" uniqKey="Horrobin D" first="D. F." last="Horrobin">D. F. Horrobin</name></region><name sortKey="Ally, A I" sort="Ally, A I" uniqKey="Ally A" first="A. I." last="Ally">A. I. Ally</name><name sortKey="Ally, A I" sort="Ally, A I" uniqKey="Ally A" first="A. I." last="Ally">A. I. Ally</name><name sortKey="Horrobin, D F" sort="Horrobin, D F" uniqKey="Horrobin D" first="D. F." last="Horrobin">D. F. Horrobin</name><name sortKey="Karmali, R A" sort="Karmali, R A" uniqKey="Karmali R" first="R. A." last="Karmali">R. A. Karmali</name><name sortKey="Karmali, R A" sort="Karmali, R A" uniqKey="Karmali R" first="R. A." last="Karmali">R. A. Karmali</name><name sortKey="Karmazyn, M" sort="Karmazyn, M" uniqKey="Karmazyn M" first="M." last="Karmazyn">M. Karmazyn</name><name sortKey="Karmazyn, M" sort="Karmazyn, M" uniqKey="Karmazyn M" first="M." last="Karmazyn">M. Karmazyn</name><name sortKey="Manku, M S" sort="Manku, M S" uniqKey="Manku M" first="M. S." last="Manku">M. S. Manku</name><name sortKey="Manku, M S" sort="Manku, M S" uniqKey="Manku M" first="M. S." last="Manku">M. S. Manku</name><name sortKey="Morgan, R O" sort="Morgan, R O" uniqKey="Morgan R" first="R. O." last="Morgan">R. O. Morgan</name><name sortKey="Morgan, R O" sort="Morgan, R O" uniqKey="Morgan R" first="R. O." last="Morgan">R. O. Morgan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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